Fresh frozen plasma can be store at -40C for up to 10 years. Pooled platelets from multiple donors from whole blood collections are cheaper to produce but the exposure to the recipient increases. Contains RBC, plasma, and plasma proteins. 4. Front Pediatr. However, when the endothelial layer is broken, the fibers that form blood vessels are exposed to the blood flow. When the plasma sample is frozen within 8 hours of collection, it is called fresh-frozen plasma (FFP). FFP can be used to treat coagulation factor deficiencies found in disease states including . Transfus Apher Sci. However, if your facility does not transfuse the product within 24 hours, you would have to re-label the unit as "Thawed Plasma". Plasma derivatives like special plasma proteins can be obtained by fractionation. Freaking out. Would you like email updates of new search results? It may also be used as the replacement fluid in plasma exchange. 1. Thrombopoietin is the hormone that controls the development of megakaryocytes. Bookshelf These platelets are active. The plasma is then virally inactivated Found insideThe goal of Vignettes in Patient Safety is to illustrate and discuss, in a clinically relevant format, examples in which evidence-based approaches to patient care, using established methodologies to develop highly functional ... Viruses that cause HIV, hepatitis B and C, are destroyed by treating with heat or solvent detergents. FFP transfusion has limited efficacy and is associated with significant morbidity in critically ill patients, in particular, pulmonary edema and acute lung injury. Bethesda, MD 20894, Help Mortality was also significantly higher in patients who received transfusions than in those who did not, regardless of whether the transfusions were red blood cells (2.5% vs 0.2%; P < .01), fresh frozen plasma (3.3% vs 0.5%; P < .01), or platelets (4.7% vs 0.8%; P < .01). Found inside – Page iiThis book provides a comprehensive overview of damage control resuscitation (DCR), an evidence-based approach to the resuscitation of patients with severe life-threatening hemorrhage (LTH). Asprin can prevent blood clotting by platelets. Shankar-Hari M, Estcourt L, Harvala H, Roberts D, Menon DK; United Kingdom SARS-CoV-2 Convalescent Plasma Evaluation (SCoPE) Consortium. 8600 Rockville Pike Agitation of bag is used to prevent platelets from sticking to bag. Careers. Plasma suspends blood cells and other important substances. An Australian handbook to support the safe administration of blood and blood products by health professionals at the patient's side. Bethesda, MD 20894, Help Typically, neither blood cells stick to the endothelial layer. Fresh frozen plasma and cryoprecipitate, platelet transfusions, and clotting factor transfusions are also available. Plasma is a straw-colored liquid. Plasma is mainly composed of water (93% by volume). What are Fresh Frozen Plasma (FFP) and Cryoprecipitate? Plasma carries blood cells and other substances around our body. Cryoprecipitate may be indicated if the plasma fibrinogen is less than 1 g/l, although there is no clear threshold for Plasma derivatives are covered by the Medicines Act and, like any other . We hypothesized that fresh frozen plasma (FFP) resuscitation would attenuate platelet dysfunction compared with 0.9% normal saline (NS). Plasma components of any RhD type can be given regardless to the RhD type of the recipient. Inactive platelets are disk-shaped. PubMed Citation 9. Approaches to platelet refractoriness: 1. Epub 2020 Sep 18. For platelet transfusion, the American Society of Clinical Oncology has developed practice guidelines designed for oncology patients. This is the 5th edition of this publication and it supersedes the 4th ed. (2007) (ISBN 9780113226771). As platelets are the smallest and the lightest blood cells in the blood, they are pushed away from the central blood flow inside the blood vessels. Cryoprecipitated AHF, pooled. Fresh frozen plasma (FFP) is the accepted standard treatment for clotting factor replacement in bleeding patients during or immediately after cardiac surgery. However, 11% stated that their most frequent use of fresh frozen plasma was solely to treat hypovolemia, a practice generally not recommended. FFP is indicated when a patient has MULTIPLE factor deficiencies and is BLEEDING. The median number of total allogeneic units transfused (packed cells and blood products) was significantly reduced in the TEG group compared with the other group (median 2, range 1-3 units vs. median 3, range 2-4 units, respectively, p = 0.001). The need for . It contains a range of coagulation factors but virtually no platelets.If ABO type-specific plasma is not available, plasma of a different ABO group may be used as long as it does not have high titers of anti-A or anti-B. Other single-donor plasma units, either frozen or liquid, may be substituted for FFP. Thus, platelets attract the fibers, becoming active. Found insideA practical, user-friendly guide to the management of sick children, written by experienced paediatric emergency physicians and anaesthetists. Description Fresh frozen plasma (FFP) is plasma frozen within six to eight hours of collection (de- FFP for use in paediatrics is collected from non UK donors, to reduce the risk of transmission of variant CJD. Description Fresh frozen plasma (FFP) is plasma frozen within six to eight hours of collection (de- Table 2.2 Choice of group of red cells, platelets, fresh frozen plasma (FFP) and cryoprecipitate according to recipient's ABO group When plasma is given prophylactically prior to invasive procedures, the timing of ad-ministration should take into account the half-life of the coagulation factor(s) in need of re-placement. Prevention and treatment information (HHS). Fresh Frozen Plasma Transfusion- Guideline for practice Background Fresh Frozen Plasma (FFP) for adult use is produced from voluntary blood donations collected in the UK. Routine minimally invasive critical care procedures can be safely performed by experienced clinicians in the setting of mildly abnormal coagulation test results, and there is no evidence that FFP transfusion alters the risk of bleeding. Risk factors, management, and outcomes of amniotic fluid embolism: A multicountry, population-based cohort and nested case-control study. Plasma is the liquid portion of blood; our red and white blood cells and platelets are suspended in plasma as they move throughout our bodies.. Color: Yellowish Shelf Life: 1 year Storage Conditions: Frozen Key Uses: Burn patients, Shock, Bleeding disorders Blood plasma serves several important functions in our bodies, despite being about 92% water. Practice parameter for the use of fresh-frozen plasma, cryoprecipitate, and platelets. Platelets: pooled and apheresis; Frozen plasma (FP) Apheresis fresh frozen plasma (AFFP) Cryosupernatant plasma (CSP) Cryoprecipitate; Brief descriptions of the indications, contraindications, storage and transportation requirements, dose, administration and available alternatives are included in the sections below. Found insideHere, two of the foremost cardiothoracic surgeons have brought together many of the top cardiologists and haematologists to produce the most current reference source on all aspects of blood conservation, from an overall clinical approach to ... 2009 Aug;67(2):221-7; discussion 228-30. doi: 10.1097/TA.0b013e3181ad5957. Results: 2. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine. However, blood component transfusions may result in adverse effects including the transmission of infection, immunosuppression and lung injury 3. This site needs JavaScript to work properly. This bestselling manual covers all aspects of intensive care in sufficient detail for daily practice while keeping you up to date with the latest innovations in the field. A blood transfusion was defined as the infusion of any plasma-containing blood product, including RBCs, platelets, fresh-frozen plasma (FFP), or cryoprecipitates. Laboratory studies should be repeated and subsequent transfusion decisions should be guided by lab results, maintaining a six to six to one ratio of packed red blood cells to fresh frozen plasma and pheresed platelets4 & 9. Dried plasma was used during WWII, and provided for transfusions to soldiers in combat. The main function of platelets is to prevent bleeding. Plasma serves as the main medium for the transportation of excretory products. What are the Similarities Between Platelets and Plasma – Outline of Common Features 4. Plasma held at room temperature for up to 24 hours (PF24RT24) Fresh frozen plasma (FFP) Plasma, cryoprecipitate reduced. Pathogen(s) Test for Platelets For information on billing for HCPCS code P9100 (pathogen(s) test for platelets) refer to the Pathology: Microbiology section of the appropriate Part 2 manual. Please enable it to take advantage of the complete set of features! DOI:10.15347/wjm/2014.010. This guide contains a compendium of measures designed to ensure the safety, efficacy and quality of blood components and is particularly intended for all those working in blood transfusion services. As noted last time, fresh frozen plasma (frozen within 8 hours, FFP) and frozen plasma (frozen within 24 hours, FP) have a shelf life of 5 days once thawed. Liquid plasma. Both platelets and plasma are two components of blood in vertebrates. Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht BG, Moore EE, Cuschieri J, Maier RV, Billiar TR, Peitzman AB; Inflammation and Host Response to Injury Investigators. Fresh-frozen plasma (from apheresis collection) Cryoprecipitate plasma (cryo) Cryosupernatant plasma (cryo-poor plasma) Preparation Whole blood is centrifuged at high speed, allowing separa-tion of plasma, red blood cells (RBCs), and the buffy coat layer (platelets, white blood cells, some RBCs and plasma). Found insidePresents information on the journal "Transfusion Medicine," published by Blackwell Science Ltd. for the British Blood Transfusion Society. The journal publishes articles, reports, and practice guidelines on transfusion medicine. Found insideThis trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. Liquid plasma (never frozen, LQP) is good for the 21 days after the original unit was donated, plus the same 5 days, for a total of 26 days. In view of the importance of making AB plasma readily available, AB cryoprecipitate manufacture and availability is a low priority for the UK Blood Services. What is the Difference Between Follicular and... What is the Difference Between Sarcolemma and... What is the Difference Between Osteons and Osteocytes, What is the Difference Between Epimysium and Fascia. Plasma: Plasma accounts for 55% of the whole blood. Treating a patient with massive bleeding is a challenge for the anesthesiologist, who is responsible for assessing the epidemiology, physiology, clinical, treatment, monitoring and prognosis of these patients. Plasma is the liquid component of blood, and is mostly made of water. What is Plasma – Definition, Composition, Function 3. Found inside – Page iMollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. Patte, A. Willems, D. Datoussaid and P. Van Der LindenIntroductionCyanotic disease is associated with altered platelet function and low fibrinogen level that could increase the risk of bleeding and therefore the exposure to blood products ... This book offers a comprehensive summary of transfusion triggers for red blood cells in specific ICU patient populations and specific conditions with the aim to personalize transfusion strategy. Please enable it to take advantage of the complete set of features! 2003;17(1):66-8. doi: 10.2165/00063030-200317010-00006. Hoffman, Matthew. Epub 2017 Aug 2. BioDrugs. Fresh Frozen Plasma 1 Unit cryoprecipitate + 1 Unit plasma (Cryoprecipitate-Reduced) Centrifuge Centrifuge Freeze, Thaw, Freeze within 8 hr* Centrifuge 1 Unit Platelets What is "FFP"? Clipboard, Search History, and several other advanced features are temporarily unavailable. Found inside – Page iiiThe first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. Huber J, Stanworth SJ, Doree C, Fortin PM, Trivella M, Brunskill SJ, Hopewell S, Wilkinson KL, Estcourt LJ. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. Plasma transfusion is done for trauma patients, patients with severe liver diseases, and in multiple clotting factor deficiencies. Platelets: Platelets are administered to clients who are adversely affected with a platelet deficiency or a serious bleeding disorder, such as thrombocytopenia or platelet dysfunction that requires the clotting factors that are in platelets. Lifeblood manufactures three plasma products as described below. Transfusion of red blood cells, fresh frozen plasma, or platelets is an independent risk factor of mortality and infection, and combination of the 3 blood products is associated with adverse outcomes after cardiac surgery in a dose-dependent manner. What About FFP Made from Apheresis Collections? Of course, I didn't think about it when I was ON SHIFT. Fresh frozen plasma. Platelets are stored at room temperature and CANNOT be frozen. Loss of clotting factors and natural anti-coagulants are recognized side effects. A survey of physicians' reasons to transfuse plasma and platelets in the critically ill: a prospective single-centre cohort study. Other available features: CMV negative, Irradiated, for pediatric use. Tuan TA, Ha NTT, Xoay TD, My TTK, Nghiem LT, Dien TM. The clumping of platelets on the fibers forms the initial seal that prevents the leakage of red blood cells from the blood vessel. Fresh Frozen Plasma (FFP) Fresh Frozen Plasma. Cryoprecipitated AHF. Commonly known as the Red Book, Guidelines for the Blood Transfusion Services in the United Kingdom 8th Edition contains best practice guidelines for all materials produced by the United Kingdom Blood Transfusion Services (UKBTS) for both ... A blood component prepared from whole blood or collected by apheresis, frozen within time limits and at a temperature such as to preserve the labile clotting factors adequately 3 - 5.. FFP prepared from units of whole blood and that derived from apheresis are therapeutically equivalent in terms of haemostasis and side effects (Grade of recommendation: 1A) 4. It is used to treat conditions in which there are low blood clotting factors (INR > 1.5) or low levels of other blood proteins. It is common clinical practice to correct these tests with fresh frozen plasma (FFP) or platelet transfusions prior to invasive procedures. 8600 Rockville Pike Recipient(s) will receive an email with a link to 'Quality Indicators of Fresh Frozen Plasma and Platelet UtilizationThree College of American Pathologists Q-Probes Studies of 8 981 796 Units of Fresh Frozen Plasma and Platelets in 1639 Hospitals' and will not need an account to access the content. Seventeen patients received massive MBC transfusions (ie, > 10 U of blood transfused within 24 h), of whom 13 also received fresh-frozen plasma (FFP) and 11 received platelet transfusions. AHF, Plasma Cryoprecipated: ≤ -18° C: MAINTAIN FROZEN STATE: AHF Pooled Cryoprecipitated (before freezing) Plasma, Frozen Within 24 Hours After Phlebotomy: Plasma, Cryoprecipitate Reduced: FFP - Plasma, Fresh Frozen: ≤ -18° C OR ≤ -65° C: ≤ -18° C OR ≤ -65° C Fresh Frozen Plasma Transfusion- Guideline for practice Background Fresh Frozen Plasma (FFP) for adult use is produced from voluntary blood donations collected in the UK. eCollection 2021. 1, 2 However, whether the prophylactic use of FFP and platelets in these patients is beneficial and truly indicated is increasingly debated. When do you give platelets vs FFP? Update on pathogen reduction technology for therapeutic plasma: an overview. 2020 Jul 20;24(1):449. doi: 10.1186/s13054-020-03163-3. Although FFP can partially correct abnormal coagulation, a recent systematic review revealed no randomized trials showing clinical benefit. Found inside – Page iCompletely condensed and revised, the fourth edition of this comprehensive reference offers a complete exploration of the basic concepts of pediatric anesthesia, with detailed descriptions of the most effective techniques for use in a wide ... Acad Emerg Med. Prophylactic plasma transfusion for patients without inherited bleeding disorders or anticoagulant use undergoing non-cardiac surgery or invasive procedures. Filed Under: Uncategorized. Fresh frozen plasma represents plasma that has been separated and frozen within 6 hours of collection. Their granules contain other proteins involved in the formation of a firm plug, sealing the blood vessel break. Ask for fresh units. The development of platelets is shown in figure 1. “FreshFrozenPlasma” By DiverDave – Own work (CC BY-SA 3.0) via Commons Wikimedia, Lakna, a graduate in Molecular Biology & Biochemistry, is a Molecular Biologist and has a broad and keen interest in the discovery of nature related things, What are the Similarities Between Platelets and Plasma, What is the Difference Between Platelets and Plasma. FFP must be used immediately after thawing and must be ABO compatible. Blood is composed of blood cells and plasma. Plasma is the straw-colored liquid in which the blood cells and other substances are suspended in. This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. Saadah NH, van Hout FMA, Schipperus MR, le Cessie S, Middelburg RA, Wiersum-Osselton JC, van der Bom JG. “1908 Platelet Development” By OpenStax College – Anatomy & Physiology, Connexions Web site, Jun 19, 2013 (CC BY 3.0) via Commons Wikimedia 2. Four to five platelet concentrates, one unit single-donor aphaeresis platelets or one unit fresh whole blood provide a quantity of coagulation factors similar to that contained in one unit FFP. Although it is intuitive that these components would be transfused in the context of bleeding, their use in neonatology has often been on a prophylactic basis. Disclaimer, National Library of Medicine No References for this article. It also maintains a satisfactory blood pressure and volume, balances the body pH, and serves as a medium for exchanging minerals like sodium and potassium. Using ABO compatible plasma, while not required, may be recommended. Warner MA, Chandran A, Jenkins G, Kor DJ. METHODS Twelve swine were subjected to multisystem trauma (traumatic brain injury, liver injury, rib fracture, and soft tissue injury) with hemorrhagic shock (40% of estimated blood volume). Found insideThis eBook provides access to the complete book content electronically. Pageburst (formerly Evolve eBooks) allows you to quickly search the entire book, make notes, add highlights, and study more efficiently. “1909 Blood Clotting” By OpenStax College – Anatomy & Physiology, Connexions Web site, Jun 19, 2013. Fresh frozen plasma infusion can be used for reversal of anticoagulant effects. It contains many factors necessary for clotting and is often given to reverse a patient's INR. Both platelets and plasma have a critical function in the body. “Picture of Blood.” WebMD, WebMD, Available here. PMC Platelets are a type of blood cells, involved in blood clotting. Found insideComprehsive and clinically oriented, the authors offer in-dept, authoritative guidance on clinical problems from a multitude of perspectives. The proteins on the surface of platelets allow them to stick to the walls of the blood vessels as well as with each other. doi: 10.1002/14651858.CD012745.pub2. In this volume, he reviews those advances and recalls his time at the NBRL. LQP is not used at most US trauma centers. • Platelets should be given in a dose of 10 - 20 ml.kg-1. Fresh Frozen Plasma (FFP) is defined as the fluid portion of one unit of human blood that has been centrifuged, separated, and frozen solid at -18 C (or colder) within 6 hours of collection. Fresh Frozen Plasma Use HCPCS codes P9017, P9023, P9059 or P9060 for reimbursement of fresh frozen plasma. Plasma: Plasma is a straw-colored, liquid component of blood where blood cells are suspended. Cryoprecipitate Same storage as FFP (cannot be re-frozen as FFP once it is separated); -18 for 1 year If thawed, store at room temp 4 hrs The leftover plasma is called cryoprecipitate reduced or plasma cryo Good for thrombocytopenic purpura (TTP) CRYO is used for 2° treatment for Factor VIII deficiency (Hemophilia A) 2 ° treatment for von Willebrand's Disease Impact of transfusion of fresh-frozen plasma and packed red blood cells in a 1:1 ratio on survival of emergency department patients with severe trauma. Plasma can be separated from its cellular portion by centrifugation. Both fresh frozen plasma (FFP) and platelets are heavily used in massive transfusion. Pathogen reduction for FFP is now well established in Europe, with solvent detergent and methylene blue methods licensed, and the psoralen amotosalen in trial. 6WB vs. RBCs + FFP + platelets = no statistically significant difference. 2017 Sep;57(9):2104-2114. doi: 10.1111/trf.14245. Although FFP can partially correct abnormal coagulation, a recent systematic review revealed no randomized trials showing clinical benefit. Each 150 ml bag contains all clotting factors, albumin and gamma-globulin. Epub 2020 Nov 29. FRESH FROZEN PLASMA A. Transfus Med Hemother. Transfusion. Found insideThis edition; Compiled by a world class Editor team including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee, and international contributor team ... Clipboard, Search History, and several other advanced features are temporarily unavailable. Would you like email updates of new search results? 2009 May;16(5):371-8. doi: 10.1111/j.1553-2712.2009.00386.x. Pathogen(s) Test for Platelets For information on billing for HCPCS code P9100 (pathogen(s) test for platelets) refer to the Pathology: Microbiology section of the appropriate Part 2 manual. Levels of the labile coagulation factors V and VIII may be slightly lower in FP in comparison with FFP. FFP and Cryoprecipitate (often just called 'cryo') are both blood components made from plasma. For platelet components, risks may be reduced by platelet additive solution, allowing removal of 70% of plasma. • Fresh frozen plasma may be given in doses of 10 - 15 ml.kg-1. Correspondingly, is fresh frozen plasma the same as platelets? Fresh frozen plasma infusion can be used for reversal of anticoagulant effects.Platelet transfusion is indicated to prevent hemorrhage in patients with thrombocytopenia or platelet function defects.. How quickly does FFP affect INR? apheresis platelets leukocytes reduced e3077 apheresis platelets|acd -a/xx/20 - 24c|resleu:<5e6 platelets lpaa apheresis platelets leukoc ytes reduced (1st container) c. Platelets. What is the Difference Between Tuberosity and... What is the Difference Between Sports and Hobbies, What is the Difference Between Blanking and Punching, What is the Difference Between Coffee Shop and Fine Dining Restaurant, What is the Difference Between Internship and Apprenticeship, What is the Difference Between Information Literacy and Media Literacy, What is the Difference Between Plagiarism and Copyright Infringement. When the plasma sample is frozen within 8 hours of collection, it is called fresh-frozen plasma (FFP). Prophylactic Plasma Transfusion Is Not Associated With Decreased Red Blood Cell Requirements in Critically Ill Patients. A pool of platelets derived from the buffy coat of four whole blood donations. JAMA 1994;271:777-781. This is because we are infusing anywhere between 250 and 400 mL of plasma, which contains ABO antibodies, making this scenario significantly more scary than transfusion of smaller amounts of . ISSN 2002-4436. What is the Difference Between Platelets and Plasma – Comparison of Key Differences, Key Terms: Blood, Circulation, Clotting, Fresh-Frozen Plasma (FFP), Frozen Plasma (FP), Plasma, Plasma, , Platelets. Leucodepleted. Likewise, does fresh frozen plasma increase platelets? After preservation by adding anticoagulants, frozen plasma can be stored up to one year at -18 ºC. Fresh Frozen Plasma. This book stands alone as one of the few texts that addresses transfusion issues specific to pediatric medicine. Written in an eminently readable style, this authoritative handbook is a requirement for any pediatric physician or caregiver. Fitzpatrick KE, van den Akker T, Bloemenkamp KWM, Deneux-Tharaux C, Kristufkova A, Li Z, Schaap TP, Sullivan EA, Tuffnell D, Knight M. PLoS Med. Home » Science » Biology » Human Anatomy » Difference Between Platelets and Plasma. If your facility thaws Fresh Frozen Plasma and transfuses it within 24 hours, then you are not required to re-label the unit and can just handwrite the new expiration date/time. 2007 Jul;35(7):1655-9. doi: 10.1097/01.CCM.0000269370.59214.97. fresh frozen plasma and platelets compared with the other group (p = 0.001). Convalescent plasma to treat critically ill patients with COVID-19: framing the need for randomised clinical trials. Epub 2009 Mar 16. Platelets: Platelets and leukocytes account for less than 1% of whole blood. Too many platelets increase the risk of blood clots. Transfusion in critically ill children: indications, risks, and challenges. This new edition of the comprehensive guide to transfusion medicine is now fully revised and updated. Both fresh frozen plasma (FFP) and platelets are heavily used in massive transfusion. Plasma compatibility. (CC BY 3.0) via Commons Wikimedia 4. MeSH FFP = "fresh frozen platelets" or "fresh frozen plasma". When it is frozen longer than 8 hours but less than 24 hours, the plasma sample is called frozen plasma (FP). Platelets: Platelets are small, colorless, disk-shaped cell fragments found in large numbers in the blood. Plasma frozen within 8 hours is called fresh frozen plasma (FFP); plasma frozen at slightly longer intervals (typically up to 24 hours) after collection is referred to as frozen plasma (known as F24 in the U.S.). Found insideA unique question-and-answer book for surgical residents and trainees that covers all surgical aspects of critical care and acute or emergency medicine This is a comprehensive, one-of-a-kind question-and-answer text for medical ... Bookshelf 8. Given over 15-30 minutes. 2019 Nov 12;16(11):e1002962. Accessibility Platelets refer to small, colorless, disk-shaped cell fragments found in large numbers in blood, involving in blood clotting. http://usmlefasttrack.com/?p=5645 Blood, Transfusion, Therapy, -, Packed, RBCs,, Platelets,, Fresh, Frozen, Plasma, &, Cryoprecipitate, Findings, symptoms, . Platelets. The remaining plasma may be labeled as "Fresh Frozen Plasma," if frozen within 6 hours after filling the final container or within the timeframe specified in the directions for use for the blood collecting, processing, and storage system. Used to treat thrombocytopenia & platelet dysfunction.